Berberine Balance supplies berberine combined with alpha lipoic acid and grape seed extract for healthy blood sugar and cardiovascular support. Recent studies indicate that berberine, a naturally occurring alkaloid found in a number of plants, is an effective supplement for helping to maintain cardiometabolic health. Berberine has been shown to regulate glucose and lipid metabolism in vitro and in vivo, providing support for healthy blood glucose and lipid levels. Experiments have also shown cardiovascular benefits of berberine, including vasorelaxatory effects. Grape seed extract and alpha lipoic acid are well-known antioxidants. Proanthocyanidins found in grape seeds appear to be especially effective in neutralizing highly reactive hydroxyl and singlet oxygen radicals, while alpha lipoic acid has been called the “universal antioxidant” due to its involvement in multiple antioxidative functions throughout the body.